Publications

• Ashtiwi NM, Kim SO, Chandler JD, Rada B.

The therapeutic potential of thiocyanate and hypothiocyanous acid against pulmonary infections.

Free Radic Biol Med. 2024 Jul;219:104-111. Epub 2024 Apr 11. PMID: 38608822

• Krepuska M, Mayer B, Vitale-Cross L, Myneni VD, Boyajian MK, Németh K, Szalayova

I, Cho T, McClain-Caldwell I, Gingerich AD, Han H, Westerman M, Rada B, Mezey É.

Bone marrow stromal cell-derived hepcidin has antimicrobial and immunomodulatory activities.

Sci Rep. 2024 Feb 17;14(1):3986. PMID: 38368463

2023

• Almeida NBF, Fantone KM, Sarr D, Ashtiwi NM, Channell S, Grenfell RFQ, Martins-Filho OA, Rada B.

Variant-dependent oxidative and cytokine responses of human neutrophils to SARS-CoV-2 spike protein and anti-spike IgG1 antibodies.

Front Immunol. 2023 Oct 16;14:1255003. PMID: 37908356.

• Fantone KM, Stevenko AA, Goldberg JB, Rada B.

Sputum from people with cystic fibrosis compromises the killing of methicillin-resistant Staphylococcus aureus by neutrophils via reduced phagosomal production of reactive oxygen species.

Pathogens 2023. Sept 9. 12(9): 1148.

• Yadav R, Li QZ, Bridges L, Kahlenberg JM, Huang H, Stecenko AA* and Rada B*.

* co-senior authors

Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection or cystic fibrosis-related diabetes.

Front Immunol. 2023 Sep 11:14:1151422.

• Miller A, Fantone KM, Tucker SL, Gokanapudi N, Goldberg JB, Rada B.

Short chain fatty acids reduce the respiratory burst of human neutrophils in response to cystic fibrosis isolates of Staphylococcus aureus.

J Cyst Fibros. 2023 May 19:S1569-1993(23)00128-5. PMID: 37211502

• Gupta T, Sarr D, Fantone K, Ashtiwi NM, Sakamoto K, Quinn FD* and Rada B*.

* co-senior authors

Dual oxidase 1 is dispensable during Mycobacterium tuberculosis infection in mice.

Front Immunol. 2023 Mar 3;14:1044703. PMID: 36936954.

2022

• Ashtiwi NM, Sarr D, Nagy T, Reneer ZB, Tripp RA and Rada B.

The hypothiocyanite and amantadine combination treatment prevents lethal influenza A

virus infection in mice.

      Front Immunol. 2022 May 18;13:859033. PMID: 35663985

• Andresen S, Fantone KM, Chapla D, Rada B, Moremen KW, Pierce M and Szymanski CM.

Human Intelectin-1 Promotes Cellular Attachment and Neutrophil Killing of Streptococcus

pneumoniae in a Serotype-Dependent Manner.

      Infection and Immunity. 2022 May 2:e0068221. PMID: 35499339

• Linnemann RW, Yadav R, Zhang C, Sarr D, Rada B, Stecenko AA.

Serum anti-PAD4 autoantibodies are present in cystic fibrosis children and increase with age and lung disease severity.

Autoimmunity. 2022 Mar;55(2):109-117.

2021

• Almutairi F, Sarr D, Tucker SL, Fantone K, Lee JK, Rada B.

RGS10 Reduces Lethal Influenza Infection and Associated Lung Inflammation in Mice.

Front Immunol. 2021 Nov 29;12:772288.

• Yassine E, Rada B.

Microbicidal Activity of Hypothiocyanite against Pneumococcus.

Antibiotics (Basel). 2021 Oct 28;10(11):1313.

• Sarr D, Oliveira LJ, Russ BN, Owino SO, Middii JD, Mwalimu S, Ambasa L, Almutairi F, Vulule J, Rada B, Moore JM.

Myeloperoxidase and Other Markers of Neutrophil Activation Associate With Malaria and Malaria/HIV Coinfection in the Human Placenta.

Front Immunol. 2021 Oct 19;12:682668.

• Tucker SL, Sarr D, Rada B.

Granulocytic Myeloid-Derived Suppressor Cells in Cystic Fibrosis.

Front Immunol. 2021 Sep 21;12:745326. Review.

• Almutairi F, Tucker SL, Sarr D, Rada B.

PI3K/ NF-κB-dependent TNF-α and HDAC activities facilitate LPS-induced RGS10 suppression in pulmonary macrophages.

Cell Signal. 2021 Oct;86:110099.

• Soumana IH, Linz B, Dewan KK, Sarr D, Gestal MC, Howard LK, Caulfield AD, Rada B, Harvill ET.

Modeling Immune Evasion and Vaccine Limitations by Targeted Nasopharyngeal Bordetella pertussis Inoculation in Mice.

Emerg Infect Dis. 2021 Aug;27(8):2107-2116.

• Fantone K, Tucker SL, Miller A, Yadav R, Bernardy EE, Fricker R, Stecenko AA, Goldberg JB, Rada B.

Cystic Fibrosis Sputum Impairs the Ability of Neutrophils to Kill Staphylococcus aureus.

Pathogens. 2021 Jun 4;10(6):703.

• Sarr D, Gingerich AD, Asthiwi NM, Almutairi F, Sautto GA, Ecker J, Nagy T, Kilgore MB, Chandler JD, Ross TM, Tripp RA, Rada B.

Dual oxidase 1 promotes antiviral innate immunity.

Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2017130118

• Ashtiwi NM, Sarr D, Rada B.

DUOX1 in mammalian disease pathophysiology.

J Mol Med (Berl). 2021 Jun;99(6):743-754. Review.

• Gold JE, Hurley DJ, Rada B, Baumgartl WH, Tilley LP, Licht WE.

Reply to Marakasova and Baranova, “MMR Vaccine and COVID-19: Measles Protein Homology May Contribute to Cross-Reactivity or to Complement Activation Protection”.

mBio. 2021 Feb 2;12(1):e03682-20.

• Tucker SL, Sarr D, Rada B.

Neutrophil extracellular traps are present in the airways of ENaC-overexpressing mice with cystic fibrosis-like lung disease.

BMC Immunol. 2021 Jan 21;22(1):7.

2020

• Thomas C, Nothaft H, Yadav R, Fodor C, Alemka A, Oni O, Bell M, Rada B, Szymanski CM.

Characterization of ecotin homologs from Campylobacter rectus and Campylobacter showae.

PLoS One. 2020 Dec 30;15(12):e0244031.

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• Williams TL, Rada B, Tandon E, Gestal MC.

“NETs and EETs, a Whole Web of Mess”.

Microorganisms. 2020 Dec 4;8(12):1925.

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• Yadav R, Linnemann RW, Kahlenberg JM, Bridges LS Jr, Stecenko AA, Rada B.

IgA autoantibodies directed against self DNA are elevated in cystic fibrosis and associated with more severe lung dysfunction.

Autoimmunity. 2020 Dec;53(8):476-484.

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• Gold JE, Baumgartl WH, Okyay RA, Licht WE, Fidel PL Jr, Noverr MC, Tilley LP, Hurley DJ, Rada B, Ashford JW.

Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients.

mBio. 2020 Nov 20;11(6):e02628-20.

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• Almutairi F, Lee JK, Rada B.

Regulator of G protein signaling 10: Structure, expression and functions in cellular physiology and diseases.

Cell Signal. 2020 Aug 31:109765.

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• Gingerich AD, Doja F, Thomason R, Tóth E, Bradshaw JL, Douglass MV, McDaniel LS and Rada B. 

Oxidative killing of encapsulated and nonencapsulated Streptococcus pneumoniae by lactoperoxidase-generated hypothiocyanite.
PLoS One. 2020 Jul 30;15(7):e0236389. PMID: 32730276. Link. Download PDF -PlosOne

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• Earls RH, Menees KB, Chung J, Gutekunst CA, Lee HJ, Hazim MG, Rada B, Wood LB, Lee JK.

NK cells clear α-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of α-synucleinopathy.

Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1762-1771.

2019

• Rada B.
  Neutrophil Extracellular Traps.
  Methods Mol Biol. 2019;1982:517-528. PMID: 31172493. Review. Download pdf.
• Cyr JL, Gawriluk TR, Kimani JM, Rada B, Watford WT, Kiama SG, Seifert AW, Ezenwa VO.
  Regeneration-Competent and -Incompetent Murids Differ in Neutrophil Quantity and Function.
  Integr Comp Biol. 2019 Apr 15.
• Yadav R, Yoo DG, Kahlenberg JM, Bridges SL Jr, Oni O, Huang H, Stecenko A, Rada B.
  Systemic levels of anti-PAD4 autoantibodies correlate with airway obstruction in cystic fibrosis.
  J Cyst Fibros. 2019 Jan 10. pii: S1569-1993(18)30971-8. doi: 10.1016/j.jcf.2018.12.010.    Press on this article (CF Research News).

2018

• Reaves BJ, Wallis C, McCoy CJ, Lorenz WW, Rada B, Wolstenholme AJ.
  Recognition and killing of Brugia malayi microfilariae by human immune cells is dependent on the parasite sample and is not altered by ivermectin treatment.
  Int J Parasitol Drugs Drug Resist. 2018 Sep 22.
• Patel U, Gingerich A, Widman L, Sarr D, Tripp RA, Rada B.
  Susceptibility of influenza viruses to hypothiocyanite and hypoiodite produced by lactoperoxidase in a cell-free system.
  PLoS One. 2018 Jul 25;13(7):e0199167.
• Sarr D, Tóth E, Gingerich A and Rada B.
  Antimicrobial actions of dual oxidases and lactoperoxidase.
  Journal of Microbiology. 2018 Jun;56(6):373-386. Download PDF – JM Sarr2018 Review

2017

• Schechter MC, Buac K, Adekambi T, Cagle S, Celli J, Ray SM, Mehta CC, Rada B* and Rengarajan J* (*, equal contributions as senior authors).
  Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB.
  PLoS One. 2017 Aug 4;12(8):e0182587. Download PDF – pone.0199167 
• Lee J, Luria A, Rhodes C, Raghu H, Lingampalli N, Sharpe O, Rada B, Sohn DH, Robinson WH, Sokolove J.
  Nicotine drives neutrophil extracellular traps formation and accelerates collagen-induced arthritis.
  Rheumatology (Oxford). 2017 Apr 1;56(4):644-653. Access to pdf online.
• Acuff NV, Li X, Elmore J, Rada B, Watford WT.
  Tpl2 promotes neutrophil trafficking, oxidative burst, and bacterial killing.
  Journal of Leukocyte Biology. 2017 Mar 29. pii: jlb.3A0316-146R.
• Rada B.
  Interactions between Neutrophils and Pseudomonas aeruginosa in Cystic Fibrosis.
  Pathogens. 2017 Mar 9;6(1). pii: E10. Review. Access to pdf online.
• Rada B.
  Neutrophil Extracellular Traps and Microcrystals.
  Journal of Immunology Research. 2017;2017:2896380. Access to pdf online.
• Sil P, Wicklum H, Surell C, Rada B.
  Macrophage-derived IL-1β enhances monosodium urate crystal-triggered NET formation.
  Inflammation Research. 2017 Mar;66(3):227-237. Access to pdf online.
• Rada B.
  Neutrophil extracellular trap release driven by bacterial motility: Relevance to CF lung disease.
  Communicative and Integrative Biology. 2017 Feb 17;10(2):e1296610. Access to pdf online.
• McCoy CJ, Reaves BJ, Giguère S, Coates R, Rada B, Wolstenholme AJ.
  Human Leukocytes Kill Brugia malayi Microfilariae Independently of DNA-Based Extracellular Trap Release.
  PLoS Neglected Tropical Diseases. 2017 Jan 3;11(1):e0005279. Access to pdf online.
• Sil P, Hayes CP, Reaves BJ, Breen P, Quinn S, Sokolove J and Rada B.
  P2Y6 receptor antagonist, MRS2578, inhibits neutrophil activation and aggregated NET formation induced by gout-associated monosodium urate crystals.
  Journal of Immunology. 2017 Jan 1;198(1):428-442. Access to pdf online.

2016

• Floyd M, Winn M, Cullen C, Sil P, Chassaing B, Yoo DG, Gewirtz AT, Goldberg JB, McCarter LL and Rada B.
  Swimming motility mediates the formation of neutrophil extracellular traps induced by flagellated Pseudomonas aeruginosa.
  PLoS Pathogens. 2016 Nov 17;12(11):e1005987. Access to pdf online.
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  Bronchiectasis News Today   UGA Today   ScienceDaily    ContagionLive    Phys.org
• Sil P, Yoo DG, Floyd M, Gingerich A and Rada B.
  High throughput measurement of extracellular DNA release and quantitative NET formation in human neutrophils in vitro.
  Journal of Visualized Experiments (JOVE). 2016 Jun 18;(112). Access to pdf online.
• Gingerich A, Pang L,Hanson J, Dlugolenski D, Streich R, Lafontaine ER, Nagy T, Tripp RA* and Rada B* (*, equal contributions as senior authors).
  Hypothiocyanite produced by human and rat respiratory epithelial cells inactivates extracellular H1N2 influenza A virus.
  Inflammation Research. 2016 Jan;65(1):71-80.

2014

• Yoo DG, Floyd M, Winn M, Moskowitz SM, Rada B.
  NET formation induced by Pseudomonas aeruginosa cystic fibrosis isolates measured as release of myeloperoxidase–DNA and neutrophil elastase–DNA complexes.
  Immunology Letters. 2014 Aug;160(2):186-94.
• Yoo DG, Winn M, Pang L, Moskowitz SM, Malech HL, Leto TL and Rada B.
  Release of cystic fibrosis airway inflammatory markers from Pseudomonas aeruginosa-stimulated human neutrophils involves NADPH oxidase-dependent extracellular DNA trap formation.
  Journal of Immunology. 2014 May 15;192(10):4728-38. Access to pdf online.
• Kuriakose T, Rada B, Watford WT.
  Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling.
  Journal of Biological Chemistry. 2014 Dec 26;289(52):36089-100. Access to pdf online.
• Rada B, Park JJ, Sil P, Geiszt M, Leto TL.
  NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases.
  Inflammation Research. 2014 Oct;63(10):821-30. Access to pdf online.

2013

• Pang L, Hayes CP, Buac K, Yoo DG, Rada B.
  Pseudogout-associated inflammatory calcium pyrophosphate dihydrate microcrystals induce formation of neutrophil extracellular traps.
  Journal of Immunology. 2013 Jun 15;190(12):6488-500. Access to pdf online.
• Rada B, Leto TL.
  Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections.
  Trends in Microbiology. 2013 Feb;21(2):73-81. Review. Access to pdf online.